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Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > Myc Family > Didymin
Didymin

CAS:14259-47-3

Appearance:White to off-white solid

Storage:Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months

Purity:HPLC≥98%

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Didymin
Cat.No：
ID0810
Brand：
Solarbio
SKU Tongzhou Beijing Haidian Beijing Wuhan Guangzhou
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Product Information Related Products Related Paper COA Technical Q&A

Didymin has antioxidant properties. Apoptosis was induced by inhibition of N-Myc and up-regulation of RKIP. Didymin has been reported to have anti-inflammatory activity after acute liver injury, hyperglycemia-induced endothelial dysfunction, and death.


Examples of using this product（for reference only）

In Vivo：

Mice（372 C57BL/6 mice (male, weight about 25 g) ）, I.P，0.5, 1.5, 4.5 mg/kg)：

Three doses of Didymin (0.5, 1.5, 4.5 mg/kg, Solarbio, China) were administered intraperitoneally at 1 h after ICH insult. Mice were randomly divided into 5 groups: sham, ICH+vehicle (DMSO), ICH+Didymin (0.5 mg/kg), ICH+Didymin (1.5 mg/kg), and ICH+Didymin (4.5 mg/kg). Neurological test, brain water content, and Evans blue (EB) extravasation were evaluated at 24 h after ICH.

Reference：

Gu L, Sun M, Li R, Zhang X, Tao Y, Yuan Y, Luo X, Xie Z. Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage. Front Immunol. 2022 Jan 27;13:810582. doi: 10.3389/fimmu.2022.810582. PMID: 35154128; PMCID: PMC8828494.

Remark：
These protocols are for reference only. Solarbio does not independently validate these methods.

Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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