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CAS:14259-47-3
Storage:Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity:HPLC≥98%
Appearance:White to off-white Solid
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Didymin has antioxidant properties. Apoptosis was induced by inhibition of N-Myc and up-regulation of RKIP. Didymin has been reported to have anti-inflammatory activity after acute liver injury, hyperglycemia-induced endothelial dysfunction, and death.
Examples of using this product（for reference only）
In Vivo：
Mice（372 C57BL/6 mice (male, weight about 25 g) ）, I.P，0.5, 1.5, 4.5 mg/kg)：
Three doses of Didymin (0.5, 1.5, 4.5 mg/kg, Solarbio, China) were administered intraperitoneally at 1 h after ICH insult. Mice were randomly divided into 5 groups: sham, ICH+vehicle (DMSO), ICH+Didymin (0.5 mg/kg), ICH+Didymin (1.5 mg/kg), and ICH+Didymin (4.5 mg/kg). Neurological test, brain water content, and Evans blue (EB) extravasation were evaluated at 24 h after ICH.
Reference：
Gu L, Sun M, Li R, Zhang X, Tao Y, Yuan Y, Luo X, Xie Z. Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage. Front Immunol. 2022 Jan 27;13:810582. doi: 10.3389/fimmu.2022.810582. PMID: 35154128; PMCID: PMC8828494.
