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My CartCAS：13190-97-1
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 13190-97-1 |
| Name | Solanesol |
| Molecular Formula | C45H74O |
| Molecular Weight | 631.07 |
| Solubility | Soluble in Methanol ≥1mg/mL(Need ultrasonic) |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 603-532-7 |
| MDL | MFCD00070279 |
| SMILES | C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CO |
| Target Point | FAK |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Solanesol is an aliphatic terpene alcohol, which mainly exists in solanaceous plants, has anti-inflammatory, neuroprotective and antibacterial activities, and has inhibitory activity against FAK. |
| Biological Activity | Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.[1] |
| In Vitro | Solanesol is widely used as an intermediate for the synthesis of ubiquinone drugs，such as coenzyme Q10 and vitamin K2 as well as Vitamin K and Vitamin E. It is known to possess activities like antibacterial，antifungal，antiviral，anticancer，anti-inflammatory，and anti-ulcer activities. Solanesol binds at ATP binding site and inhibit the phosphorylation of Focal Adhesion Kinase(FAK)[1]. Solanesol upregulates HO-1 and Hsp70 expression in L02 cells which activate Nrf2 and HSF1. It induces Nrf2 by enhancement of Keap1 interaction with Hsp90. Solanesol-activated HSF1 is involved in chaperones interaction. Solanesol also inhibits LDH，AST，MDA and ROS level，but increases the GSH level and promotes tBHQ-mediated protective effects[2]. |
| Cell Experiment | Cell viability is determined by MTT assays. Cells are seeded into 96-well plates(5 × 104 cells/well)24 h before treatment. The cells are then treated with various concentrations of solanesol followed by incubating with 5 mg/ml of MTT working solution for 4 h at 37 °C. After being treated with 100 μL of DMSO to dissolve the crystals，the cells are detected under an Microplate Reader to measure the absorbance at 570 nm.[2] |
| Data Literature Source | [1] Betty Daneial，et al. Biorxiv. 2016. [2] Yao X，et al. Toxicol In Vitro. 2015，29(3):600-8. |
| Unit | Piece |
| Specification | 100mg 200mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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