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My Cart> Small Molecule Compounds > Anti-Infection > Anti-Fungal > Terbinafine HydrochlorideCAS：91161-71-6
Molecular Formula：C21H25N
Molecular Weight：291.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 91161-71-6 |
| Name | Terbinafine Hydrochloride |
| Molecular Formula | C21H25N |
| Molecular Weight | 291.43 |
| Solubility | Soluble in DMSO ≥25mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 245-385-8 |
| MDL | MFCD00242672 |
| SMILES | CN(C/C=C/C#CC(C)(C)C)CC1=C2C=CC=CC2=CC=C1 |
| InChIKey | DOMXUEMWDBAQBQ-WEVVVXLNSA-N |
| InChI | InChI=1S/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+ |
| PubChem CID | 1549008 |
| Target Point | Fungal |
| Passage | Anti-infection |
| Background | It is an allylamine antifungal compound, which inhibits squalene cyclooxygenase in the process of ergosterol synthesis in fungal cells, and enables squalene to accumulate in cells and play a bactericidal role. |
| Biological Activity | Terbinafine (TDT 067) 是治疗真菌感染的抗真菌药物。它是来自念珠菌属的角鲨烯环氧化酶有效的非竞争性抑制剂， Ki值为30 nM。[1-2] |
| IC50 | Ki: 30nM(squalene epoxidase)[1] |
| Data Literature Source | [1]. Ryder NS，et al. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-7. [2]. Mieth H，et al. Preclinical evaluation of terbinafine in vivo. Clin Exp Dermatol. 1989 Mar;14(2):104-7. |
| Unit | Piece |
| Specification | 100mg 10mM*1mL in DMSO 200mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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