Nocodazole_Microtubule/Tubulin_Cytoskeleton_Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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Chemical Synthesis

SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
IN0710-10mg	Inquiry	Inquiry	Inquiry	Inquiry
IN0710-50mg	Inquiry	Inquiry	Inquiry	Inquiry

CAS	31430-18-9
Chinese Name	诺考达唑
English Name	Nocodazole
Synonym	Oncodazole;R17934
Unit	Piece
Purity	≥98%
Molecular Formula	C₁₄H₁₁N₃O₃S
Molecular Weight	301.32
Appearance	Light yellow to yellow solid
Storage	Powder : 2-8℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO
MDL	MFCD00005588
EC	EINECS 250-626-5
InChIKey	KYRVNWMVYQXFEU-UHFFFAOYSA-N
InChI	InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
PubChem CID	4122
SMILES	O=C(OC)NC1=NC2=CC=C(C(C3=CC=CS3)=O)C=C2N1
Description	Nocodazole is a rapidly reversible microtubule inhibitor. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly kinetics, thereby preventing mitosis and inducing tumor cell apoptosis.
Target Point	Microtubule/Tubulin
Passage	Cytoskeleton
Data Literature Source	[1]. Park H, et al. Nocodazole is a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK. ChemMedChem. 2012 Jan 2;7(1):53-6. [2]. Keliang Xu, et al. Interaction of nocodazole with tubulin isotypes. Drug Development Research 2002 [3]. Long BH, et al. Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase. Cancer Res. 1994 Aug 15;54(16):4355-61. [4]. Wang YJ, et al. Ketoconazole potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. Mol Carcinog. 2002 Aug;34(4):199-210. [5]. Signoretto E, et al. Nocodazole Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2016;38(1):379-92. [6]. Zhang JP, et al. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage. Genome Biol. 2017 Feb 20;18(1):35.
Specification	10mg 50mg