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Ruxolitinib

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Cat.No：IR0410 Solarbio

CAS：941678-49-5

Molecular Formula：C₁₇H₁₈N₆

Molecular Weight：306.37

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	941678-49-5
Name	Ruxolitinib
Molecular Formula	C₁₇H₁₈N₆
Molecular Weight	306.37
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 1312995-182-4
MDL	MFCD12031592
SMILES	N#CC[C@H](C1CCCC1)N2N=CC(C3=C4C=CNC4=NC=N3)=C2
Target Point	JAK
Passage	JAK/STAT Signaling
Background	Ruxolitinib is a potent and selective JAK1/2 inhibitor.
Biological Activity	Ruxolitinib 是有效，选择性的 JAK1/2 抑制剂， IC50 值分别为 3.3 nM和2.8 nM，选择性是 JAK3 的 130 多倍。[1-3]
IC50	JAK2:2.8nM;JAK1:3.3nM;Tyk2:19nM [1-3]
Data Literature Source	[1]. Quintas-Cardama A，et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood，2010，115(15)，3109-3117. [2]. Verstovsek S，et al. A double-blind，placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med，2012，366(9)，799-807. [3]. Harrison C，et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med. 2012 Mar 1;366(9):787-98.
Unit	Piece
Specification	5mg 10mM*1mL in DMSO 10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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