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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > SP600125CAS：129-56-6
Molecular Formula：C14H8N2O
Molecular Weight：220.23
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
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| CAS | 129-56-6 |
| Name | SP600125 |
| Molecular Formula | C14H8N2O |
| Molecular Weight | 220.23 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 204-955-6 |
| MDL | MFCD00022289 |
| SMILES | O=C1C2=C3C(NN=C3C4=C1C=CC=C4)=CC=C2 |
| InChIKey | ACPOUJIDANTYHO-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) |
| PubChem CID | 8515 |
| Target Point | Ferroptosis;JNK |
| Passage | Apoptosis;MAPK |
| Background | It is a potent, reversible, ATP-competitive JNK inhibitor and also a potent ferroptosis inhibitor. |
| Biological Activity | SP600125是一种可逆，ATP竞争性的 JNK 抑制剂，抑制 JNK1， JNK2 和 JNK3 的 IC50 分别为 40, 40, 90 nM。[1-5] |
| Data Literature Source | [1]. Bennett BL，et al. SP600125，an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A，2001，98(24)，13681-13686. [2]. Vaishnav D，et al. SP600125，an inhibitor of c-jun N-terminal kinase，activates CREB by a p38 MAPK-mediated pathway. Biochem Biophys Res Commun，2003，307(4)，855-860. [3]. Kim JA，et al. SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase，independent of JNK inhibition. Oncogene，2010，29(11)，1702-1716. [4]. Zheng Y，et al. JNK inhibitor SP600125 protects against lipopolysaccharide-induced acute lung injury via upregulation ofclaudin-4. Exp Ther Med. 2014 Jul;8(1):153-158. [5]. Zhang H，et al. SP600125 Suppresses Keap1 Expression and Results in NRF2-mediated Prevention of Diabetic Nephropathy. J Mol Endocrinol. J Mol Endocrinol. 2018 Feb;60(2):145-157. |
| Unit | Piece |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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