SP600125_Apoptosis_Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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CAS	129-56-6
Chinese Name	吡唑蒽酮
English Name	SP600125
Synonym	1，9-吡唑并蒽酮;吡唑蒽酮;二苯并[cd，g]吲唑-6(2H)-酮;2H-Dibenzo[CD，G]Indazol-6-One
Unit	Piece
Purity	≥98%
Molecular Formula	C₁₄H₈N₂O
Molecular Weight	220.23
Appearance	Solid
Storage	Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO
EC	EINECS 204-955-6
MDL	MFCD00022289
InChIKey	ACPOUJIDANTYHO-UHFFFAOYSA-N
InChI	InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
PubChem CID	8515
SMILES	O=C1C2=C3C(NN=C3C4=C1C=CC=C4)=CC=C2
Description	It is a potent, reversible, ATP-competitive JNK inhibitor and also a potent ferroptosis inhibitor.
Target Point	Ferroptosis;JNK
Passage	Apoptosis;MAPK
Data Literature Source	[1]. Bennett BL, et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A, 2001, 98(24), 13681-13686. [2]. Vaishnav D, et al. SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway. Biochem Biophys Res Commun, 2003, 307(4), 855-860. [3]. Kim JA, et al. SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition. Oncogene, 2010, 29(11), 1702-1716. [4]. Zheng Y, et al. JNK inhibitor SP600125 protects against lipopolysaccharide-induced acute lung injury via upregulation ofclaudin-4. Exp Ther Med. 2014 Jul;8(1):153-158. [5]. Zhang H, et al. SP600125 Suppresses Keap1 Expression and Results in NRF2-mediated Prevention of Diabetic Nephropathy. J Mol Endocrinol. J Mol Endocrinol. 2018 Feb;60(2):145-157.
Specification	10mg 10mM*1mL in DMSO 50mg