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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Hippo > VerteporfinCAS：129497-78-5
Molecular Formula：C41H42N4O8
Molecular Weight：718.79
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 129497-78-5 |
| Name | Verteporfin |
| Molecular Formula | C41H42N4O8 |
| Molecular Weight | 718.79 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28098202 |
| SMILES | C[C@]1(/C2=C/C(N3)=C4C)C(C(/C=C(C(C)=C/5C=C)\NC5=C/C6=N/C(C(CCC(OC)=O)=C6C)=C\C3=C4CCC(O)=O)=N2)=CC=C(C(OC)=O)[C@H]1C(OC)=O.C[C@]7(/C8=C/C(N9)=C%10C)C(C(/C=C(C(C)=C/%11C=C)\NC%11=C/C%12=N/C(C(CCC(O)=O)=C%12C)=C\C9=C%10CCC(OC)=O)=N8)=CC=C(C(OC)=O)[C@H]7C(OC)=O |
| Target Point | YAP;TEAD;Autophagy;Apoptosis |
| Passage | Hippo |
| Background | Verteporfin is a YAP inhibitor that disrupts the YAP-TEAD interaction. |
| Biological Activity | Verteporfin是一种用于光动力疗法的光敏剂，用于消除与年龄相关的黄斑变性等疾病相关的眼内异常血管。 Verteporfin是一种 YAP 抑制剂，可破坏YAP-TEAD相互作用。[1-2] |
| Data Literature Source | [1]. Morishita T，et al. The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with dasatinib. Oncotarget. 2016 Aug 2. [2]. Pan W，et al. Verteporfin can Reverse the Paclitaxel Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression. Cell Physiol Biochem. 2016;39(2):481-90. |
| Unit | Piece |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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PLAGL2 promotes bladder cancer progression via RACGAP1/RhoA GTPase/YAP1 signaling
Click to check >>Author：Chen Hualin, Yang Wenjie, Li Yingjie, Ji Zhigang
IF：9.0000
Publish_to：Cell Death & Disease
PMID：37454211
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