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Navitoclax

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Cat.No：IN0750 Solarbio

CAS：923564-51-6

Molecular Formula：C₄₇H₅₅ClF₃N₅O₆S₃

Molecular Weight：974.61

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	923564-51-6
Name	Navitoclax
Molecular Formula	C₄₇H₅₅ClF₃N₅O₆S₃
Molecular Weight	974.61
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00004550
SMILES	O=S(C1=CC(S(NC(C2=CC=C(N3CCN(CC4=C(CCC(C)(C4)C)C5=CC=C(Cl)C=C5)CC3)C=C2)=O)(=O)=O)=CC=C1N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)(C(F)(F)F)=O
Target Point	Bcl-2 Family;Bcl-w;Bcl-xL
Passage	Apoptosis
Background	Navitoclax is a potent Bcl-2 inhibitor.
Biological Activity	Navitoclax 是有效的 Bcl-2 抑制剂，可与Bcl-xL，Bcl-2， Bcl-w等多种Bcl-2家族蛋白结合，Ki 值小于 1 nM[1-3]。
Data Literature Source	[1]. Lock R1，et al. Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008 Jun;50(6):1181-1189. [2]. Wong M，et al. Navitoclax (ABT-263) reduces Bcl-x(L)-mediated chemoresistance in ovarian cancer models.Mol Cancer Ther. 2012 Apr;11(4):1026-1035. [3]. Ackler S，et al. Navitoclax (ABT 263) and Bendamustine±Rituximab Induce Enhanced Killing of Non-Hodgkin's Lymphoma Tumors in Vivo. Br J Pharmacol. 2012 Oct;167(4):881-891.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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