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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > Sorafenib TosylateCAS：475207-59-1
Molecular Formula：C21H16ClF3N4O3·C7H8SO3
Molecular Weight：637.03
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 475207-59-1 |
| Name | Sorafenib Tosylate |
| Molecular Formula | C21H16ClF3N4O3·C7H8SO3 |
| Molecular Weight | 637.03 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 641-758-8 |
| MDL | MFCD08235032 |
| SMILES | O=S(C1=CC=C(C=C1)C)(O)=O.O=C(NC2=CC=C(C(C(F)(F)F)=C2)Cl)NC3=CC=C(OC4=CC(C(NC)=O)=NC=C4)C=C3 |
| Target Point | Ferroptosis;Raf |
| Passage | Apoptosis;MAPK |
| Background | Sorafenib Tosylate is a multi-kinase inhibitor that inhibits VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit. Sorafenib Tosylate is an effective inhibitor of Raf. Sorafenib Tosylate is also a ferroptosis agonist. |
| Biological Activity | Sorafenib tosylate是一种有效的多激酶抑制剂，抑制Raf-1，B-Raf 和 VEGFR-3 的 IC50 分别为6 nM，20 nM 和 22 nM。[1-4] |
| Data Literature Source | [1]. Wilhelm SM，et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109. [2]. Huynh H，et al. Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Cell Mol Med. 2009 Aug;13(8B):2673-83. [3]. El-Ashmawy NE，et al. Sorafenib effect on liver neoplastic changes in rats: more than a kinase inhibitor. Clin Exp Med. 2016 Apr 16. [4]. Zhu W，et al. Combination of sorafenib and Valproic acid synergistically induces cell apoptosis and inhibits hepatocellular carcinoma growth via down-regulating Notch3 and pAkt. Am J Cancer Res. 2017 Dec 1;7(12):2503-2514 |
| Unit | Bottle |
| Specification | 50mg 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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