Vincristine sulfate_Microtubule/Tubulin_Cytoskeleton_Inhibitors & Antagonists & Agonists_Small Molecule Compounds

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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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CAS	2068-78-2
Chinese Name	硫酸长春新碱
English Name	Vincristine sulfate
Synonym	硫酸长春新碱；LY170053;替莫唑胺;硫酸醛基长春碱;长春新碱硫酸盐;
Purity	HPLC≥98%
Unit	Bottle
Molecular Formula	C₄₆H₅₈N₄O₁₄S
Molecular Weight	923.04
Appearance	White to off-white solid
Storage	Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in water/DMSO≥10mg/ml
MDL	MFCD00084729
EC	EINECS 218-190-0
SMILES	CC[C@@]1(C=CCN2CC3)[C@@]2([H])[C@@]3(C4=CC([C@](C5=C6C7=CC=CC=C7N5)(C[C@](C[C@](CC)(O)C8)([H])C[N@@]8CC6)C(OC)=O)=C(OC)C=C4N9C=O)[C@]9([H])[C@](C(OC)=O)(O)[C@@H]1OC(C)=O.O=S(O)(O)=O
Description	Vincristine sulfate is an alkaloid that inhibits microtubule formation in the mitotic spindle, resulting in arrest of dividing cells in metaphase. Inhibits microtubule polymerization by binding to tubulin
Target Point	Microtubule/Tubulin
Passage	Cytoskeleton
Data Literature Source	[1]. Jordan, M.A., et al. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res, 1985. 45 (6) : p. 2741-7. [2]. Gidding, C.E., et al, Vincristine revisited. Crit Rev Oncol Hematol, 1999. 29 (3) : p. 267-87. [3]. Donoso, J.A., et al, Action of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on axonal fibrillar organelles in vitro. Cancer Res, 1977. 37 (5) : p. 1401-7. [4]. Horton, J.K., et al. Relationships between tumor responsiveness, vincristine pharmacokinetics and arrest of mitosis in human tumor xenografts. Biochem Pharmacol, 1988. 37 (20) : p. 3995-4000. [5]. Baguley, B.C., et al, Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism. Eur J Cancer, 1991. 27 (4) : p. 482-7. [6]. Zhang D, et al. Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance. Int J Nanomedicine. 2017 Mar 16; 12:2081-2108.
Specification	5mg 10mg 10mM*1mL in DMSO 20mg