English Name |
Anti-PSMC1 Polyclonal Antibody |
Chinese Name |
ATP酶蛋白酶体26S亚基1抗体 |
Target |
PSMC1 |
Synonym |
26S protease regulatory subunit 4, P26S4, p56, Proteasome (prosome macropain) 26S subunit ATPase 1, Proteasome 26S ATPase subunit 1, Proteasome 26S subunit ATPase 1, PSMC 1, PSMC1, S4, PRS4_HUMAN |
Backgroud |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. |
Swiss Prot |
P62191 |
Gene ID |
5700 |
Subcellular Localization |
Cytoplasm Nucleus |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
41/49kDa |
Dilution Ratio |
WB 1:1000-3000. IHC 1:50-200. |
Immunogen |
Recombinant protein of human PSMC1 |
Public Immunogen Range |
93-440aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Monkey Mouse |
Application |
WB IHC |
Specification |
50ul 100ul |