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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > AT9283CAS：896466-04-9
Molecular Formula：C19H23N7O2
Molecular Weight：381.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 896466-04-9 |
| Name | AT9283 |
| Molecular Formula | C19H23N7O2 |
| Molecular Weight | 381.43 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12031513 |
| SMILES | O=C(NC1CC1)NC2=CNN=C2C3=NC4=CC=C(C=C4N3)CN5CCOCC5 |
| Target Point | JAK2/3;AuroraA，AuroraB;Bcr-Abl |
| Passage | Cell Cycle;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK |
| Background | AT9283 is a multi-targeted kinase inhibitor that effectively inhibits Aurora A/B, JAK2/3. |
| Biological Activity | AT9283是一种多靶点激酶抑制剂，有效抑制Aurora A/B，JAK2/3 (IC50=1.2 nM, 1.1 nM)[1-3]。 |
| IC50 | JAK2:1.2nM;JAK3:1.1nM Aurora A:3nM;Aurora B:3nM Abl(T315I):4nM [1-3] |
| Data Literature Source | [1]. Howard S，et al. Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283)，a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity. Journal of Medicinal Chemistry (2009)，52(2)，379-388. [2]. Qi W，et al. AT9283，a novel aurora kinase inhibitor，suppresses tumor growth in aggressive B-cell lymphomas. Int J Cancer. 2012 Jun 15;130(12):2997-3005. [3]. Santo L，et al. Antimyeloma activity of a multitargeted kinase inhibitor，AT9283，via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide. Clin Cancer Res. 2011 May 15;17(10):3259-71 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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