{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > TW-37CAS：877877-35-5
Molecular Formula：C33H35NO6S
Molecular Weight：573.7
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 877877-35-5 |
| Name | TW-37 |
| Molecular Formula | C33H35NO6S |
| Molecular Weight | 573.7 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD17010275 |
| SMILES | O=C(C1=CC(CC2=CC=CC=C2C(C)C)=C(C(O)=C1O)O)NC3=CC=C(C=C3)S(=O)(C4=CC=CC=C4C(C)(C)C)=O |
| Target Point | Bcl-2 Family |
| Passage | Apoptosis |
| Background | TW-37 is a potent Bcl-2 inhibitor. |
| Biological Activity | TW-37 是一种有效的 Bcl-2 抑制剂，作用于 Mcl-1，Bcl-2 和 Bcl-xL，Ki 值分别为 260，290 和 1110 nM。[1-2] |
| Data Literature Source | [1]. Zeitlin BD，et al. Antiangiogenic effect of TW37，a small-molecule inhibitor of Bcl-2. Cancer Res. 2006 Sep 1;66(17):8698-706. [2]. Mohammad RM，et al. Preclinical studies of TW-37，a new nonpeptidic small-molecule inhibitor of Bcl-2，in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1. Clin Cancer Res. 2007 Apr 1;13(7):2226-35 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
