{{cart_num}}
My CartCAS：850876-88-9
Molecular Formula：C35H46FN5O9S
Molecular Weight：731.83
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 850876-88-9 |
| Name | Danoprevir |
| Molecular Formula | C35H46FN5O9S |
| Molecular Weight | 731.83 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16038038 |
| SMILES | O=S(NC([C@@]1(NC([C@]2([H])C[C@@H](OC(N3CC4=C(C3)C=CC=C4F)=O)CN2C5=O)=O)C[C@]1(/C=C/CCCCC[C@@H]5NC(OC(C)(C)C)=O)[H])=O)(C6CC6)=O |
| Target Point | HCV Protease |
| Passage | Metabolic Enzyme/Protease |
| Background | Danoprevir is a peptidomimetic inhibitor that inhibits HCV NS3/4A protease. |
| Biological Activity | Danoprevir 是一种模拟肽类抑制剂, 能够抑制 HCV NS3/4A protease, IC50 值为 0.2-3.5 nM[1-3]。 |
| IC50 | IC50: 0.2-3.5nM (NS3/4A protease) [1-3] |
| Data Literature Source | [1]. Imhof I， et al. Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191) .Hepatology. 2011 Apr; 53 (4) :1090-9. [2]. Seiwert， Scott D.， et al. Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227) . Antimicrobial Agents and Chemotherapy (2008) ， 52 (12) ， 4432-4441. [3]. Bartels DJ， et al. Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects. J Infect Dis. 2008 Sep 15; 198 (6) :800-7 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
