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TRAM-34

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Cat.No：IT1310 Solarbio

CAS：289905-88-0

Molecular Formula：C₂₂H₁₇ClN₂

Molecular Weight：344.84

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	289905-88-0
Name	TRAM-34
Molecular Formula	C₂₂H₁₇ClN₂
Molecular Weight	344.84
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD09842562
SMILES	ClC1=CC=CC=C1C(N2N=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4
InChIKey	KBFUQFVFYYBHBT-UHFFFAOYSA-N
InChI	InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
PubChem CID	656734
Target Point	Potassium Channel
Passage	Membrane Transporter&Ion Channel
Background	TRAM-34 is a selective calcium-activated K+ channel (IKCa1) blocker.
Biological Activity	TRAM-34 是一种选择性的钙激活 K+ 通道 (IKCa1)阻断剂，Kd 为 20 nM。[1]
Data Literature Source	[1]. Wulff H，et al. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel，IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8151-6. [2]. Roy JW，et al. The intermediate conductance Ca2+-activated K+ channel inhibitor TRAM-34 stimulates proliferation of breast cancer cells via activation of oestrogen receptors. Br J Pharmacol. 2010 Feb 1;159(3):650-8. [3]. Chen YJ，et al. The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke. J Cereb Blood Flow Metab. 2011 Dec;31(12):2363-74.
Unit	Bottle
Specification	5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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