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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > TanespimycinCAS：75747-14-7
Molecular Formula：C31H43N3O8
Molecular Weight：585.69
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 75747-14-7 |
| Name | Tanespimycin |
| Molecular Formula | C31H43N3O8 |
| Molecular Weight | 585.69 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD04973892 |
| SMILES | O=C(C(NC(/C(C)=C/C=C\[C@H](OC)[C@H](/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H](C1)C)OC)O)C)OC(N)=O)=O)=CC2=O)C1=C2NCC=C |
| Target Point | HSP90 |
| Passage | Cell Cycle;Metabolic Enzyme&Protease |
| Background | It is a potent HSP90 inhibitor. |
| Biological Activity | 17-AAG是有效的 HSP90 抑制剂, IC50 为5 nM, 对肿瘤细胞HSP90的结合亲比正常细胞高100倍[1-5]。 |
| IC50 | HSP90:5nM (IC50) [1-5] |
| Data Literature Source | [1]. Solit DB， et al. 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts.Clin Cancer Res， 2002， 8 (5) ， 986-993. [2]. Raja， Srikumar M.， et al. A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells. Cancer Biology & Therapy (2008) ， 7 (10) ， 163 [3]. Zhang J， et al. The heat shock protein 90 inhibitor 17-AAG suppresses growth and induces apoptosis in human cholangiocarcinoma cells.Clin Exp Med. 2012 Sep 7. [4]. Newman B， et al. HSP90 Inhibitor 17-AAG Selectively Eradicates Lymphoma Stem Cells.Cancer Res. 2012 Sep 1; 72 (17) :4551-61. Epub 2012 Jun 29. [5]. Kamal A， et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature. 2003 Sep 25; 425 (6956) :407-10 |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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