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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > GanetespibCAS：888216-25-9
Molecular Formula：C20H20N4O3
Molecular Weight：364.4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 888216-25-9 |
| Name | Ganetespib |
| Molecular Formula | C20H20N4O3 |
| Molecular Weight | 364.4 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 812-978-3 |
| MDL | MFCD22420818 |
| SMILES | CN1C2=CC=C(N3C(NN=C3C4=CC(C(C)C)=C(O)C=C4O)=O)C=C2C=C1 |
| Target Point | HSP90 |
| Passage | Cell Cycle;Metabolic Enzyme&Protease |
| Background | Ganetespib is an HSP90 inhibitor. |
| Biological Activity | Ganetespib是一种HSP90 抑制剂，在多种血液和实体肿瘤细胞系中表现出有效的细胞毒性[1-5]。 |
| Data Literature Source | [1]. Shimamura T，et al. Ganetespib (STA-9090)，a Non-Geldanamycin HSP90 Inhibitor，has Potent Antitumor Activity in In Vitro and In Vivo Models of Non-Small Cell Lung Cancer. Clin Cancer Res. 2012 Jul 17. [2]. Ying W，et al. Ganetespib，a unique triazolone-containing Hsp90 inhibitor，exhibits potent antitumor activity and a superior safety profile for cancer therapy. Mol Cancer Ther. 2012 Feb;11(2):475-84. [3]. London CA，et al. Phase I evaluation of STA-1474，a prodrug of the novel HSP90 inhibitor ganetespib，in dogs with spontaneous cancer.PLoS One. 2011;6(11):e27018. [4]. Proia DA，et al. Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling. PLoS One. 2011 Apr 14;6(4):e18552. [5]. Stewart E，et al. Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic，Epigenomic，and Proteomic Analyses. Cancer Cell. 2018 Sep 10;34(3):411-426.e19. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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