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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > NSC-74859CAS：501919-59-1
Molecular Formula：C16H15NO7S
Molecular Weight：365.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 501919-59-1 |
| Name | NSC-74859 |
| Molecular Formula | C16H15NO7S |
| Molecular Weight | 365.36 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09907564 |
| SMILES | OC1=CC(NC(COS(=O)(C2=CC=C(C=C2)C)=O)=O)=CC=C1C(O)=O |
| Target Point | STAT3 |
| Passage | JAK/STAT Signaling |
| Background | NSC 74859 is a selective Stat3 inhibitor. |
| Biological Activity | NSC 74859是选择性的 Stat3 抑制剂，IC50 为86±33 μM[1-3]。 |
| IC50 | STAT3:86μM [1-3] |
| Data Literature Source | [1]. Siddiquee K，et al. Selective chemical probe inhibitor of Stat3，identified through structure-based virtual screening，induces antitumor activity. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6. [2]. Lin L，et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling. Oncogene. 2009 Feb 19;28(7):961-72. [3]. Zhou C，et al. STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion. J Clin Invest. 2015 Apr;125(4):1692-702 |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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