CAS:579-13-5
Storage:Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥95%
Appearance:White to off-white Solid
Oligomycin A 是一种线粒体 F0F1-ATPase 抑制剂; Oligomycin A 具有抗真菌的功能。
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Oligomycin ACAS:579-13-5
Storage:Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥95%
Appearance:White to off-white Solid
CAS | 579-13-5 |
Chinese Name | 寡霉素A |
English Name | Oligomycin A |
Synonyms | MCH 32 |
Molecular Formula | C45H74O11 |
Molecular Weight | 791.06 |
Solubility | Soluble in DMSO |
Purity | ≥95% |
Appearance | White to off-white Solid |
Storage | Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC | EINECS 209-473-3 |
MDL | MFCD00065705 |
SMILES | O=C(/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@@H]1C)=O)O[C@@]([C@@H]2C)([H])[C@H](C)[C@@]3(CC[C@H](C)[C@H](C[C@H](O)C)O3)O[C@@]2([H])CC[C@@H](CC)/C=C/C=C/C[C@@H](C)[C@H](O)[C@@](C)(O)C1=O |
Target Point | ATP Synthase |
Passage | Membrane Transporter&Ion Channel |
Background | Oligomycin A is a mitochondrial F0F1-ATPase inhibitor; Oligomycin A has antifungal properties. |
Biological Activity | Oligomycin A 是一种线粒体 F0F1-ATPase 抑制剂,Ki 值为 1 μM;Oligomycin A 具有抗真菌的功能[1-2]。 |
In Vitro | Oligomycin A对NCI-60细胞系显示出细胞毒性,GI50为10nM。 Oligomycin A也抑制Triton X-100溶解的ATP酶的活性,Ki为0.1μM。此外,Oligomycin A具有抗真菌活性[1]。 Oligomycin A(2.4μM)抑制精子实现可行的体外获能(IVC)的能力,并抑制黄体酮诱导的体外顶体胞吐(IVAE)以及伴随的O2消耗和ATP水平峰[2]。 |
Cell Experiment | 将药物(Oligomycin A等)稀释液一式三份加入96孔板中的单层或悬浮细胞中不同时间。然后将MTT加入到孔中,终浓度为0.5mg/mL。在制备还原的MTT晶体后除去上清液。将晶体完全溶解在40mM HCl的异丙醇溶液中。将板在595nm的酶标仪上扫描[1]。 |
Data Literature Source | [1]. Salomon AR,et al. Apoptolidin,a selective cytotoxic agent,is an inhibitor of F0F1-ATPase. Chem Biol. 2001 Jan;8(1):71-80. [2]. Ramió-Lluch L,et al. Oligomycin A-induced inhibition of mitochondrial ATP-synthase activity suppresses boar sperm motility and in vitro capacitation achievement without modifying overall sperm energy levels. Reprod Fertil Dev. 2014;26(6):883-97. |
Unit | Bottle |
Specification | 1mg 5mg |
Oligomycin A 是一种线粒体 F0F1-ATPase 抑制剂; Oligomycin A 具有抗真菌的功能。