Enzastaurin
Cat.No:IE0700 Solarbio
CAS:170364-57-5
Molecular Formula:C32H29N5O2
Molecular Weight:515.6
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:Solid
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EnzastaurinCAS:170364-57-5
Molecular Formula:C32H29N5O2
Molecular Weight:515.6
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:Solid
Qty:
Size:
CAS | 170364-57-5 |
Name | Enzastaurin |
Molecular Formula | C32H29N5O2 |
Molecular Weight | 515.6 |
Solubility | Soluble in DMSO |
Purity | ≥98% |
Appearance | Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
MDL | MFCD11040980 |
SMILES | O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3C4=CN(C5CCN(CC6=NC=CC=C6)CC5)C7=C4C=CC=C7)NC3=O |
Target Point | PKCβ |
Passage | TGF-beta/Smad;Epigenetics |
Background | Enzastaurin is a potent PKCβ inhibitor. |
Biological Activity | Enzastaurin 是一种有效的 PKCβ 抑制剂,IC50 值为 6 nM;对其选择性是对 PKCα,PKCγ 和 PKCε 的 6-20 倍[1-3]。 |
IC50 | PKCα:39nM;PKCβ:6nM;PKCγ:83nM;PKCε:110nM [1-3] |
Data Literature Source | [1]. Rovedo MA,et al. Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin. J Invest Dermatol,2011,131(7),1442-1449. [2]. Podar K,et al. Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel,orally available small-molecule inhibitor enzastaurin (LY317615.HCl). Blood,2007,109(4),1669-1677. [3]. Graff JR,et al. The protein kinase Cbeta-selective inhibitor,Enzastaurin (LY317615.HCl),suppresses signaling through the AKT pathway,induces apoptosis,and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res,2005,65(16), |
Unit | Bottle |
Specification | 10mg 50mg 100mg |
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
Note:
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