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HA 14-1

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Cat.No：IH0620 Solarbio

CAS：65673-63-4

Molecular Formula：C₁₇H₁₇BrN₂O₅

Molecular Weight：409.23

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	65673-63-4
Name	HA 14-1
Molecular Formula	C₁₇H₁₇BrN₂O₅
Molecular Weight	409.23
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00218213
SMILES	BrC1=CC=C2C(C(C(C(OCC)=O)=C(O2)N)C(C#N)C(OCC)=O)=C1
InChIKey	SXJDCULZDFWMJC-UHFFFAOYSA-N
InChI	InChI=1S/C17H17BrN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3
PubChem CID	3549
Target Point	Bcl-2 Family
Passage	Apoptosis
Background	HA14-1 is a Bcl-2/Bcl-xL antagonist.
Biological Activity	HA14-1 是一种 Bcl-2/Bcl-xL 拮抗剂。HA14-1 与 Bcl-2 上的特定口袋结合, IC50 约为 9 μM，并抑制 Bcl-2 功能。[1-3]
IC50	Bcl-2: 9μM(IC50)[1-3]
Data Literature Source	[1]. Wang JL，et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7124-9. [2]. Kessel D，et al. Initiation of apoptosis and autophagy by the Bcl-2 antagonist HA14-1. Cancer Lett. 2007 May 8;249(2):294-9. [3]. Manero F，et al. The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death. Cancer Res. 2006 Mar 1;66(5):2757-64.
Unit	Bottle
Specification	10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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