Obatoclax Mesylate
Cat.No:IO0360 Solarbio
CAS:803712-79-0
Molecular Formula:C20H19N3O·CH4O3S
Molecular Weight:413.49
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥99%
Appearance:Solid
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Obatoclax MesylateCAS:803712-79-0
Molecular Formula:C20H19N3O·CH4O3S
Molecular Weight:413.49
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥99%
Appearance:Solid
Qty:
Size:
CAS | 803712-79-0 |
Name | Obatoclax Mesylate |
Molecular Formula | C20H19N3O·CH4O3S |
Molecular Weight | 413.49 |
Solubility | Soluble in DMSO |
Purity | ≥99% |
Appearance | Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC | EINECS 804-325-6 |
SMILES | COC1=CC(C2=CC3=C(C=CC=C3)N2)=N/C1=C\C4=C(C=C(N4)C)C.CS(=O)(O)=O |
Target Point | Bcl-2 Family |
Passage | Apoptosis |
Background | Obatoclax is an antagonist of BCL-2 family proteins. |
Biological Activity | Obatoclax是 BCL-2 家族蛋白的拮抗剂。它与 BCL-2 结合的Ki 为220 nM[1-5]。 |
Data Literature Source | [1]. Marina Konopleva,et al. Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax). Cancer Res May 1,2008 68; 3413 [2]. Wei WJ,et al. Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer. Theranostics. 2017 Feb 23;7(4):987-1001. [3]. Or CR,et al. Obatoclax,a Pan-BCL-2 Inhibitor,Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells. Int J Mol Sci. 2016 Dec 27;18(1). [4]. Champa D,et al. Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis. Oncotarget. 2016 Jun 7;7(23):34453-71. [5]. Nguyen M,et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7. Epub 2007 Nov 26. |
Unit | Bottle |
Specification | 2mg 10mg 20mg |
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
Note:
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