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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > FlupirtineCAS：75507-68-5
Molecular Formula：C19H21FN4O6
Molecular Weight：420.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
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| CAS | 75507-68-5 |
| Name | Flupirtine |
| Molecular Formula | C19H21FN4O6 |
| Molecular Weight | 420.39 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 278-225-0 |
| MDL | MFCD00941415 |
| SMILES | O=C(NC1=CC=C(N=C1N)NCC2=CC=C(C=C2)F)OCC.O=C(/C=C\C(O)=O)O |
| Target Point | Potassium Channel;NMDAR |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | It is a neuronal potassium channel opener and has NMDA receptor antagonist properties. |
| Biological Activity | Flupirtine Maleate is a brain penetrant，and orally bioavailable，non-opioid and centrally acting analgesic agent. Flupirtine Maleate is an indirect N-methyl-D-aspartate receptor (NMDAR) antagonist. Neuroprotective properties[1][2]. |
| Data Literature Source | [1]. Jan D rr，et al. Disease Modification in Multiple Sclerosis by Flupirtine-Results of a Randomized Placebo Controlled Phase II Trial. Front Neurol. 2018 Oct 9;9:842. [2]. Hanna M Jaeger，et al. The indirect NMDAR inhibitor flupirtine induces sustained post-ischemic recovery，neuroprotection and angioneurogenesis. Oncotarget. 2015 Jun 10;6(16):14033-44. [3]. Elango Panchanathan，Effect of flupirtine on the growth and viability of U373 malignant glioma cells.Cancer Biol Med. 2013 Sep;10(3):142-7. [4]. Martin J Gunthorpe，et al. The mechanism of action of retigabine (ezogabine)，a first-in-class K+ channel opener for the treatment of epilepsy.Epilepsia. 2012 Mar;53(3):412-24. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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