CAS:1158838-45-9
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to yellow Solid
Aurora A inhibitor I是有效,高度选择的 Aurora A 抑制剂。
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Aurora A Inhibitor ICAS:1158838-45-9
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to yellow Solid
CAS | 1158838-45-9 |
English Name | Aurora A Inhibitor I |
Synonyms | TC-S 7010;极光A抑制剂 I |
Molecular Formula | C31H31ClFN7O2 |
Molecular Weight | 588.08 |
Solubility | Soluble in DMSO |
Purity | ≥98% |
Appearance | White to yellow Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
MDL | MFCD16495816 |
SMILES | O=C(C1=CC=C(C=C1)NC2=C(F)C=NC(NC3=CC=C(C=C3)CC(N4CCN(CC4)CC)=O)=N2)NC5=CC=CC=C5Cl |
Target Point | Aurora Kinase |
Passage | Cell Cycle |
Background | Aurora A inhibitor I is a potent, highly selective Aurora A inhibitor. |
Biological Activity | Aurora A inhibitor I是有效,高度选择的 Aurora A 抑制剂,IC50值为3.4 nM[1]。 |
IC50 | Aurora A:3.4nM;Aurora B:3.4μM [1] |
In Vitro | Aurora A抑制剂I是一种有用的工具化合物,用于研究Aurora A激酶的细胞作用,而没有抑制Aurora B的并发症[1]。 |
Data Literature Source | [1]. Aliagas-Martin I,Burdick D,Corson L,Dotson J,Drummond J,Fields C,Huang OW,Hunsaker T,Kleinheinz T,Krueger E,Liang J,Moffat J,Phillips G,Pulk R,Rawson TE,Ultsch M,Walker L,Wiesmann C,Zhang B,Zhu BY,Cochran AG.A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.J Med Chem. 2009 May 28;52(10):3300-7. |
Unit | Bottle |
Specification | 10mg 50mg 100mg |
Aurora A inhibitor I是有效,高度选择的 Aurora A 抑制剂。