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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Sildenafil citrateCAS：171599-83-0
Molecular Formula：C22H30N6O4S·C6H8O7
Molecular Weight：666.7
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
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| CAS | 171599-83-0 |
| Name | Sildenafil citrate |
| Molecular Formula | C22H30N6O4S·C6H8O7 |
| Molecular Weight | 666.7 |
| Solubility | Soluble in DMSO ≥20mg/mL;Soluble in Water ＜ 1mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-659-6 |
| MDL | MFCD09026931 |
| SMILES | O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(C)CC4)=O)=CC=C3OCC)N1.O=C(CC(C(O)=O)(O)CC(O)=O)O |
| Target Point | Phosphodiesterase (PDE) |
| Passage | Metabolic Enzyme&Protease |
| Background | Sildenafil citrate is a potent phosphodiesterase 5 (PDE5) inhibitor. |
| Biological Activity | Sildenafil citrate 是一种有效的磷酸二酯酶 5 (PDE5) 抑制剂, IC50 为 5.22 nM[1]。 |
| IC50 | IC50: 5.22nM (PDE 5) [1] |
| Data Literature Source | [1]. Wang Z， et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov; 10 (11) :2790-7. [2]. Li BB， et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl) . 2011 Sep; 124 (17) :2733-40. [3]. Moretti R， et al. Sildenafil， a cyclic GMP phosphodiesterase inhibitor， induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28; 13 (1) :95. [4]. Korkmaz MF， et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar; 33 (2) :204-11. |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg 250mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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