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My Cart> Small Molecule Compounds > Anti-Infection > Antiviral > Tenofovir Disoproxil FumarateCAS：202138-50-9
Molecular Formula：C19H30N5O10P·C4H4O4
Molecular Weight：635.51
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 202138-50-9 |
| Name | Tenofovir Disoproxil Fumarate |
| Molecular Formula | C19H30N5O10P·C4H4O4 |
| Molecular Weight | 635.51 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 687-766-5 |
| MDL | MFCD08141829 |
| SMILES | O=C(OC(C)C)OCOP(OCOC(OC(C)C)=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)=O.O=C(O)/C=C/C(O)=O |
| Target Point | HIV |
| Passage | Anti-infection |
| Background | Tenofovir Disoproxil Fumarate is a nucleotide reverse transcriptase inhibitor. |
| Biological Activity | Tenofovir Disoproxil Fumarate是用于治疗 HIV 和慢性乙型肝炎的核苷酸逆转录酶抑制剂。[1-5] |
| Data Literature Source | [1]. Murphy RA，et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3) [2]. Musumeci G，et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018 [3]. Wahl A，et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098 [4]. Menne S，Cote PJ，Korba BE，Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8. [5]. Xu P，et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate，Emtricitabine，and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692. |
| Unit | Bottle |
| Specification | 50mg 100mg 250mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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