Bortezomib_Proteasome_Metabolic Enzyme & Protease_Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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CAS	179324-69-7
Chinese Name	硼替佐米
English Name	Bortezomib
Synonym	硼替佐米;MG-341;硼替佐米杂质;保特佐米;PS-341;N-(2-吡嗪羰基)-L-苯丙氨酸-L-亮氨酸硼酸;
Purity	HPLC≥98%
Unit	Bottle
Molecular Formula	C₁₉H₂₅BN₄O₄
Molecular Weight	384.24
Appearance	White to off-white solid
Storage	Powder : -20℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO≥5mg/ml
EC	EINECS 605-854-3
MDL	MFCD09056737
InChIKey	GXJABQQUPOEUTA-RDJZCZTQSA-N
InChI	InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
PubChem CID	387447
SMILES	OB(O)[C@H](CC(C)C)NC([C@@H](NC(C1=NC=CN=C1)=O)CC2=CC=CC=C2)=O
Description	It is a reversible and selective proteasome inhibitor that effectively inhibits the 20S proteasome by targeting threonine residues. Disrupts the cell cycle, induces apoptosis, and inhibits nuclear factor NF-κB.
Target Point	Proteasome
Passage	Metabolic Enzyme&Protease
IC50	Ki: 0.6 nM (20S proteasome)[1]
Data Literature Source	[1]. Adams J, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999 Jun 1;59(11):2615-22. [2]. Boccadoro M, et al. Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. Cancer Cell Int. 2005 Jun 1;5(1):18. [3]. Yerlikaya A, et al. Combined effects of the proteasome inhibitor bortezomib and Hsp70 inhibitors on the B16F10 melanoma cell line. Mol Med Rep. 2010 Mar-Apr;3(2):333-9. [4]. Yamamoto S, et al. Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats. J Pharmacol Sci. 2015 Sep;129(1):43-50.
Specification	10mg 10mM*1mL in DMSO 20mg 50mg