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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > CarfilzomibCAS：868540-17-4
Molecular Formula：C40H57N5O7
Molecular Weight：719.91
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 868540-17-4 |
| Name | Carfilzomib |
| Molecular Formula | C40H57N5O7 |
| Molecular Weight | 719.91 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 692-054-2 |
| MDL | MFCD11040997 |
| SMILES | C[C@@]1(C([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC(CN2CCOCC2)=O)CCC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)=O)OC1 |
| InChIKey | BLMPQMFVWMYDKT-NZTKNTHTSA-N |
| InChI | InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1 |
| PubChem CID | 11556711 |
| Target Point | Proteasome |
| Passage | Metabolic Enzyme&Protease |
| Background | Carfilzomib is an irreversible proteasome inhibitor. |
| Biological Activity | Carfilzomib是不可逆的蛋白酶体 (proteasome) 抑制剂，其在ANBL-6和RPMI 8226细胞中的 IC50 为5 nM。[1-2] |
| Data Literature Source | [1]. Kuhn DJ，et al. Potent activity of carfilzomib，a novel，irreversible inhibitor of the ubiquitin-proteasome pathway，against preclinical models of multiple myeloma. Blood. 2007 Nov 1;110(9):3281-90. [2]. Dasmahapatra G，et al. Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo. Mol Cancer Ther. 2011 Sep;10(9):1686-97. |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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