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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > TGF-β/Smad > GalunisertibCAS：700874-72-2
Molecular Formula：C22H19N5O
Molecular Weight：369.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 700874-72-2 |
| Name | Galunisertib |
| Molecular Formula | C22H19N5O |
| Molecular Weight | 369.42 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00001881 |
| SMILES | CC1=CC=CC(C2=NN3C(CCC3)=C2C4=CC=NC5=C4C=C(C=C5)C(N)=O)=N1 |
| InChIKey | IVRXNBXKWIJUQB-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28) |
| PubChem CID | 10090485 |
| Target Point | TGF-β Receptor |
| Passage | TGF-beta/Smad |
| Background | Galunisertib/LY2157299 is a selective TGF-β receptor inhibitor. |
| Biological Activity | Galunisertib 是一种选择性的 TGF-β 受体抑制剂，IC50 为 56 nM[1]。 |
| IC50 | 56nM(TGF-βR)[1] |
| Data Literature Source | [1]. Cong L，et al. Targeting the TGF-β receptor with kinase inhibitors for scleroderma therapy. Arch Pharm (Weinheim). 2014 Sep;347(9):609-15. [2]. Serova M，et al. Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients. Oncotarget. 2015 Aug 28;6(25):21614-27 [3]. Bueno L，et al. Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299，a new type I receptor TGF-beta kinase antagonist，in mice. Eur J Cancer. 2008 Jan;44(1):142-50. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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