Epirubicin Hydrochloride_Topoisomerase_DNA Damage & DNA Repai_Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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CAS	56390-09-1
Chinese Name	盐酸表阿霉素
English Name	Epirubicin Hydrochloride
Synonym	盐酸表柔比星;4-Epidoxorubicin hydrochloride;Pharmorubicin
Purity	HPLC≥98%
Unit	Piece
Molecular Formula	C₂₇H₂₉NO₁₁·HCl
Molecular Weight	579.98
Appearance	Orange to red solid
Storage	Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in water≥10mg/ml
EC	EINECS 260-145-2
MDL	MFCD00941448
InChIKey	MWWSFMDVAYGXBV-FGBSZODSSA-N
InChI	InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1
PubChem CID	65348
Delivery Time	1-2 days
SMILES	O=C(C1=C2C(O)=C3[C@@H](O[C@@]4([H])C[C@H](N)[C@@H](O)[C@H](C)O4)C[C@@](C(CO)=O)(O)CC3=C1O)C5=CC=CC(OC)=C5C2=O.Cl
Description	It is a semi-synthetic L-arabinose derivative of doxorubicin with antitumor activity by inhibiting topoisomerase. Also a Forkhead box protein p3 (Foxp3) inhibitor that inhibits regulatory T cell activity.
Target Point	Topoisomerase
Passage	DNA Damage/DNA Repair
Data Literature Source	[1]. Cersosimo RJ, et al. Epirubicin: a review of the pharmacology, clinical activity, and adverse effects of an adriamycin analogue. J Clin Oncol. 1986 Mar; 4 (3) :425-39.[2]. Ozkan, A., et al. Epirubicin HCl toxicity in human-liver derived hepatoma G2 cells. Pol J Pharmacol, 2004. 56 (4) : p. 435-44.[3]. Bonadonna, G., et al. Drugs ten years later: epirubicin. Ann Oncol, 1993. 4 (5) : p. 359-69.[4]. Asanuma, F., et al. Antitumor activity of paclitaxel and epirubicin in human breast carcinoma, R-27. Folia Microbiol (Praha) , 1998. 43 (5) : p. 473-4.
Specification	10mg 50mg 100mg