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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > RopivacaineCAS：84057-95-4
Molecular Formula：C17H26N2O
Molecular Weight：274.4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 84057-95-4 |
| Name | Ropivacaine |
| Molecular Formula | C17H26N2O |
| Molecular Weight | 274.4 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| EC | EINECS 200-001-8 |
| MDL | MFCD00864425 |
| SMILES | CCCN1CCCC[C@H]1C(NC2=C(C=CC=C2C)C)=O |
| InChIKey | ZKMNUMMKYBVTFN-HNNXBMFYSA-N |
| InChI | InChI=1S/C17H26N2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20)/t15-/m0/s1 |
| PubChem CID | 175805 |
| Target Point | Others |
| Passage | Others |
| Background | Ropivacaine is a potent sodium channel blocker. |
| Biological Activity | Ropivacaine 是一种有效的钠通道 (sodium channel) 阻断剂，可以作为局部麻醉试剂。Ropivacaine 通过可逆地抑制钠离子内流 (sodium ion influx) 从而引起神经纤维脉冲传导阻滞。Ropivacaine 也是一种 K2P (双孔钾通道) TREK-1 的抑制剂，在 COS-7 细胞膜上的 IC50 值为 402.7 μM。Ropivacaine 用于局部麻醉和神经性疼痛的缓解的相关研究。[1-2] |
| IC50 | 402.7μM(TREK-1 in COS-7 cell'smembrane)[2] |
| Data Literature Source | [1]. Dene Simpson，et al. Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs. 2005;65(18):2675-717. [2]. Li TF，et al. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. PLoS One. 2015 Jan 24;10(1):e0117321. |
| Unit | Bottle |
| Specification | 20mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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