Acadesine_AMPK_PI3K/Akt/mTOR_Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

Biochemical Reagents

Antibiotics (Biochemical Reagents) Vitamins Carbohydrates and Derivatives Animal & Plant Hormones Surfactants Amino Acids & Peptides & Protein Enzymes & Coenzymes & Inhibitors Bases & Nucleic Acids & Derivatives Acids & Salts & Amines Biochemical Reagents Building Blocks PEG Derivatives Universal Buffer

Protein and Immunity

Protein Extraction/Quantification Protein Electrophoresis Other Reagents Immunotechnical Services Recombinant Protein Whole Cell Protein

Small Molecule Compounds

Star Products Inhibitors & Antagonists & Agonists Peptide PROTAC Anti-Infection Plant Hormones Amino Acids & Derivatives Vitamins & Derivatives Carbohydrates & It's Analogues Cosolvent & Solubilizer Dye & Probe Reaction Substrate & Physicochemical Detection

Antibodies

Primary Antibodies Secondary Antibodies Loading Control Antibodies Label Antibodies Antigens Plant Antibodies Viral Antibodies Bacterial Antibodies Small Molecule Antibodies RNA Antibodies

ELISA

Human Rats Mice Other Species Antibody Pairs Self-Prepare Reagents

Biochemical Assay Kits

Micromethod Macromethod HPLC Anti-Reverse Series Oxidation Series Antioxidant Series Coenzyme Ⅰ Series Coenzyme Ⅱ Series Glycolysis Series Glutathione Series Vitamin C Metabolism Series ATP Series Nitrogen Metabolism Series Amino Acid Metabolism Series Esterase Series Mitochondrial Respiratory Chain Series Tricarboxylic Acid Cycle Series Protease Series Fatty Acid Metabolism Series Starch Series Sucrose Series Sugar Metabolism Series Ion Series Soil Series Signal Series Transhydrogenase Series Other Series Protein quantification Pectin Series Photosynthesis Series Gluconeogenesis Series Vitamin Series

Standard References

Star Products Control Herbs Standard Solution CP Standards Imported Standards Standard References Derivatization Reagent Ion Pair Reagents Domestic Standard Material UV Spectroscopy Standards

Dye Reagents

Stain Solution Fixation Solution Dye

Cell Biology

Cell Detection Reagents Cell Growth Factor Cell Line Cell Culture Cell Isolation & Digestion Cell Staining & Probe Cell Transfection Limulus Lysate

Molecular Biology

Nucleic Acid Extraction/Purification PCR Nucleic Acid Electrophoresis Recombinant Clone Expression Molecular Hybridization

Chromatography Media

Fillers Prepacked Column

Microbial Culture

Strains Drug Sensi-Disc Culture Medium Other

Instruments & Consumables

Consumables Imported Consumables Pipette Instruments Consignment Products

Magnetic Beads

Purified Magnetic Beads Immunoprecipitation Base Magnetic Beads

Nanomaterials

Graphite/Graphene Carbon Nanomaterials Molecular Sieve Other Nanomaterials Inorganic Nanomaterials Metallic Nanomaterial Graphenoid

Peptide

Substance P & Related Peptides Pituitary Adenylate Cyclase Activating Peptides Bag Cell Peptides Cholecystokinin RGD/RAD Peptides Opioid Peptides Cancer Research Apelin/APLN Viral-Associated Peptides Laminin Peptides Pituitary & Hypothalamic Hormone Melanocyte-Stimulating Hormone/MSH Adrenocorticotropic Hormone/ACTH Growth-Promoting Hormone Neuropeptides Thymopoietin & Thymosin Peptides Endothelin & It's Analogues Protein Kinases & Related Peptides Amyloid Peptides Multiple Sclerosis Peptide Tag Osteoporosis Research Matrix Metalloproteinase Substrate Hormones Calcitonin Antimicrobial Peptides Antioxidant Peptides Insect Neuropeptides Casein Morphine Peptides Enzyme Substrate Peptides Prolactin-Releasing Peptides Enkephalin Brain Natriuretic Peptides Endorphin & Endorphin Thrombin-Related Peptides Other Dynorphin Neurokinin Neuropeptides & Related Peptides Renal Myelin Peptides Growth Hormone & Growth Factor Somatostatin & It's Analogues Leptin Fragment Peptides Bombesin Gastrin Cell-Penetrating Peptides Fibronectin & Extracellular Matrix Peptides Anti-Inflammatory Peptides Natriuretic Peptides A Angiotensinogen Substrates & Inhibitors Angiopoietin & Angiotensin Bradykinin Thrombospondin Hematology Inflammation Research Allatostatins Inhibitor-Related Peptides Cosmetic Peptides

Chemical Synthesis

SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
IA1530-50mg	Inquiry	Inquiry	Inquiry	Inquiry
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IA1530-500mg	Inquiry	Inquiry	Inquiry	Inquiry
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CAS	2627-69-2
Chinese Name	阿卡地新
English Name	Acadesine
Synonym	5-氨基咪唑-4-甲酰胺盐酸盐;氨鲁米特
Unit	Bottle
Purity	≥98%
Molecular Formula	C₉H₁₄N₄O₅
Molecular Weight	258.23
Appearance	White to brown solid
Storage	Powder : -20℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in water/DMSO
EC	EINECS 220-097-5
MDL	MFCD00869751
InChIKey	RTRQQBHATOEIAF-UUOKFMHZSA-N
InChI	InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
PubChem CID	17513
Delivery Time	1-2 days
SMILES	OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC(C(N)=O)=C2N)O1
Description	Acadisine is an adenosine analog and an AMPK activator. Acadisine is also an autophagy, YAP and mitophagy inhibitor.
Target Point	AMPK;Autophagy;YAP;Mitophagy
Passage	PI3K/Akt/mTOR;Epigenetics
Data Literature Source	[1]. Nakamaru K, et al. AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells. Biochem Biophys Res Commun. 2005 Mar 11; 328 (2) :449-54 [2]. Drake JC, et al. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Dec; 299 (6) :R1546-54. [3]. Pold R, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats.Diabetes. 2005 Apr; 54 (4) :928-34. [4]. Chen L, et al. Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin. Front Pharmacol. 2018 Jul 16; 9:761.
Specification	10mM*1mL in DMSO 50mg 100mg 500mg