CAS |
219766-25-3 |
Chinese Name |
N-(2-((2-氧代氮杂环庚烷-3-基)氨甲酰)苯基)苯并噻吩-2-甲酰胺 |
English Name |
ANA-12 |
Synonym |
NebramycinIIsulfate |
Unit |
Bottle |
Purity |
≥98% |
Molecular Formula |
C22H21N3O3S |
Molecular Weight |
407.49 |
Appearance |
White to off-white solid |
Storage |
Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in DMSO |
MDL |
MFCD00117444 |
EC |
EINECS 803-090-7 |
InChIKey |
TUSCYCAIGRVBMD-UHFFFAOYSA-N |
InChI |
InChI=1S/C22H21N3O3S/c26-20(25-17-10-5-6-12-23-21(17)27)15-8-2-3-9-16(15)24-22(28)19-13-14-7-1-4-11-18(14)29-19/h1-4,7-9,11,13,17H,5-6,10,12H2,(H,23,27)(H,24,28)(H,25,26) |
PubChem CID |
2799722 |
Delivery Time |
1-2 days |
SMILES |
O=C(C1=CC2=CC=CC=C2S1)NC3=CC=CC=C3C(NC4C(NCCCC4)=O)=O |
Description |
ANA-12 is a potent, selective TrkB antagonist. |
Target Point |
Trk Receptor |
Passage |
Protein Tyrosine Kinase/RTK;Neuronal Signaling |
Data Literature Source |
[1]. Cazorla M, et al. Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest. 2011 May;121(5):1846-57.
[2]. Zhang JC, et al. Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression. Psychopharmacology (Berl). 2015 Dec;232(23):4325-35.
[3]. Vassoler FM, et al. Epigenetic inheritance of a cocaine-resistance phenotype. Nat Neurosci. 2013 Jan;16(1):42-7.
[4]. Fang X, et al. Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury. Eur Arch Psychiatry Clin Neurosci. 2018 Jun 7. |
Specification |
2mg 10mM*1mL in DMSO 5mg 10mg |