| CAS |
75887-54-6 |
| Chinese Name |
蒿乙醚 |
| English Name |
β-Arteether |
| Synonyms |
Arteether;(+)-Arteether;SM-227;Artemotil |
| Molecular Formula |
C17H28O5 |
| Molecular Weight |
312.4 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
White to off-white Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time |
1-2 Days |
| MDL |
MFCD00869355 |
| SMILES |
C[C@@H]1[C@@](CC[C@@H](C)[C@]2([H])CC[C@]3(C)O4)([H])[C@@]2(OO3)[C@]4([H])O[C@@H]1OCC |
| InChIKey |
NLYNIRQVMRLPIQ-XQLAAWPRSA-N |
| InChI |
InChI=1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17-/m1/s1 |
| PubChem CID |
3000469 |
| Target Point |
Parasite |
| Passage |
Anti-infection |
| Background |
β-Arteether is a semisynthetic analog of artemisinin |
| Biological Activity |
Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant Plasmodium falciparum malaria with an IC50 of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys[1-2]. |
| IC50 |
1.61nM(Plasmodium falciparummalaria)[1] |
| In Vitro |
The antimalarial activity of Artemotil is test in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. The mean 50% inhibitory concentration(IC50)for Artemotil is 1.61 nM(range 1.57-1.92 nM). Artemotil is approximately 2.5-fold more potent than artemisinin[1]. |
| In Vivo |
Artemotil treatment(25 mg/kg; intravenous injection; daily; for 7 days; Sprague-Dawley male rats)shows anorectic toxicity and causes significant reductions in food consumption and body weight after day 2. AUC on day 7 is 5-fold higher than AUC on day 1. The elimination t1/2 of Artemotil is also prolonged from 13.7 hours(day 1)to 31.2 hours(day 7)[2]. |
| Data Literature Source |
[1]. Shmuklarsky MJ，et al. Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo. Am J Trop Med Hyg. 1993 Mar;48(3):377-84.
[2]. Li QG，et al. Arteether toxicokinetics and pharmacokinetics in rats after 25 mg/kg/day single and multiple doses. Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24(3):213-23. |
| Unit |
Bottle |
| Specification |
5mg 10mg 20mg |
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