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My Cart> Antibodies > Primary Antibodies > Anti-Phospho-MLKL (S358) Polyclonal AntibodyReactivity：Human
Application：IHC,WB
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：197259
Host：Rabbit
Qty：
Size：
| Name | Anti-Phospho-MLKL (S358) Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | WB 1:500-1000. IHC 1:50-100. |
| Target | Phospho-MLKL (S358) |
| Background | Swiss-Prot Acc.Q8NB16.Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. |
| Swiss Prot | Q8NB16 |
| Gene ID | 197259 |
| Subcellular Location | Cell membrane Cytoplasm Membrane |
| Immunogen | A synthetic peptide of human Phospho-MLKL (S358) |
| Calculated MW | 54kDa |
| Purification Method | Affinity purification |
| Storage Buffer | Rabbit IgG in phosphate buffered saline，pH 7.4，150mM NaCl，0.02% sodium azide and 50% glycerol. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Unit | Piece |
| Specification | 50ul 100ul |
| Reactivity | Human |
| Application | IHC WB |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Western blot analysis with Phospho-MLKL (S358) antibody diluted at 1:1000;Lane: HT29,HT29(treated by TNF alpha+Smac mimetic+zVAD).
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