English Name |
Anti-CDKL1 Polyclonal Antibody |
Target |
CDKL1 |
Synonym |
CDC 2 related kinase 1, CDC 2 related kinase, CDC2 related kinase 1, CDC2 related kinase, CDK L1, CDKL 1, cdkl1, CDKL1_HUMAN, Cyclin dependent kinase like 1, cyclin-dependent kinase-like 1 (CDC2-related kinase), Cyclin-dependent kinase-like 1, EC 2.7.11.22, KKIALRE, p42, Protein kinase p42 KKIALRE, Serine/threonine protein kinase KKIALRE, Serine/threonine-protein kinase KKIALRE |
Backgroud |
The activation of signal transduction pathways by growth factors; hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis; kidney; brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However; unlike other MAP kinases; the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif. |
Swiss Prot |
Q00532 |
Gene ID |
8814 |
Subcellular Localization |
Cell membrane Cytoplasm |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
32/42/109kDa |
Dilution Ratio |
WB 1:1000-3000. IHC 1:50-200. |
Immunogen |
A synthetic peptide of Human CDKL1 |
Public Immunogen Range |
215-265/358aa |
Purification Method |
Octanoic acid-ammonium sulfate precipitation |
Storage Buffer |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Rat |
Application |
WB IHC |
Specification |
50ul 100ul |