CAS |
499-75-2 |
Chinese Name |
香荆芥酚 |
English Name |
Carvacrol |
Synonyms |
cymophenol;O-Thymol;Karvakrol;香芹酚 |
Molecular Formula |
C10H14O |
Molecular Weight |
150.22 |
Solubility |
Soluble in DMSO |
Purity |
HPLC≥98% |
Appearance |
Colorless to light yellow Liquid |
Storage |
Store at 2-8℃,2 years |
Density |
0.976g/mL |
EC |
EINECS 207-889-6 |
MDL |
MFCD00002236 |
SMILES |
CC(C)C1=CC(O)=C(C)C=C1 |
InChIKey |
RECUKUPTGUEGMW-UHFFFAOYSA-N |
InChI |
InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3 |
PubChem CID |
10364 |
Target Point |
Others |
Passage |
Others |
Background |
Carvacrol is a monoterpene phenol in the Lamiaceae plant with antioxidant, anti-inflammatory, and anticancer activities. Carvacrol causes G0/G1 cell cycle arrest, down-regulates Notch-1 and Jagged-1, and induces apoptosis. |
Biological Activity |
Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.[1-2] |
In Vitro |
Carvacrol(CVC)possesses weak antioxidant and cytotoxic activity in cultured primary rat neurons. In addition,Carvacrol has weak antioxidant properties and little anticancer potentials in rat N2a neuroblastoma cell line[1]. Carvacrol is a novel inhibitor of transient receptor potential(TRP)channels in drosophila and mammalian. In human hepatoma HepG2 cells,Carvacrol induces cell apoptosis by selectively decreasing phosphorylation of extracellular signal-regulated kinase 1/2(ERK1/2)and P38; In human macrophage-like U937 cells,in response to lipopolysaccharide treatment,Carvacrol activates peroxisome proliferator-activated receptors(PPAR alpha and gamma)and suppresses cyclooxygenase-2(COX-2)mRNA and protein expression[2]. |
In Vivo |
Carvacrol has the ability to protect liver against ischemia/reperfusion injury in rats. In the central nervous system,Carvacrol is regarded as a potential drug for Alzheimer's disease due to its inhibitory effect on acetylcholinesterase(AChE)activity by using phenolic hydroxyl group of carvacrol to bind to AChE and leading to a loss of function of AChE. In addition,Carvacrol is found to have an antidepressant-like effect in mice by affecting the dopaminergic system. Dietary carvacrol supplementation prevents high fat diet-induced obesity by modulating gene expressions that lead to adipogenesis and inflammation. Carvacrol crosses the blood-brain barrier easily and rapidly[2]. |
Cell Experiment |
The cells are seeded in 48-well plates. Cells are incubated at 37 °C in a humidified 5 % CO2/95 % air mixture and treated with carvacrol at different concentrations(10,25,50,100,200 and 400 mg/L)for 24 h. MTT substrate solution is used. Briefly,MTT is added to the cell cultures for 3 h. Formed formazan crystals are dissolved in dimethyl sulfoxide(DMSO),MTT is added to the cell cultures for 3 h. Formed formazan crystals are dissolved in dimethyl sulfoxide(DMSO).[1] |
Animal Experiment |
Animal Models: Male ICR mice; Dosages: 50 mg/kg; Administration: i.c.v.[2] |
Data Literature Source |
[1] Elanur Ayd n,et al. Cytotechnology. 2014,66(1): 149–157. [2] Yu H,et al. PLoS One. 2012,7(3):e33584. |
Unit |
Bottle |
Specification |
20mg 100mg 200mg |