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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > AZD-7762CAS：860352-01-8
Molecular Formula：C17H19FN4O2S
Molecular Weight：362.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 860352-01-8 |
| Name | AZD-7762 |
| Molecular Formula | C17H19FN4O2S |
| Molecular Weight | 362.42 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12406007 |
| SMILES | O=C(N[C@@H]1CNCCC1)C2=C(C=C(S2)C3=CC=CC(F)=C3)NC(N)=O |
| InChIKey | IAYGCINLNONXHY-LBPRGKRZSA-N |
| InChI | InChI=1S/C17H19FN4O2S/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24)/t12-/m0/s1 |
| PubChem CID | 11152667 |
| Target Point | Checkpoint Kinase (Chk) |
| Passage | Cell Cycle |
| Background | AZD-7762 is a potent ATP-competitive cell cycle checkpoint kinase (Chk) inhibitor. |
| Biological Activity | AZD-7762 是一种有效的ATP竞争性的Checkpoint kinase(Chk) 抑制剂，抑制Chk1的 IC50 为 5 nM[1-2]。 |
| IC50 | Chk1:5nM;Chk2:5nM [1-2] |
| Data Literature Source | [1]. Zabludoff SD，et al. AZD7762，a novel checkpoint kinase inhibitor，drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol Cancer Ther. 2008 Sep;7(9):2955-66. [2]. Quin J，et al. Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling. Oncotarget. 2016 Aug 2;7(31):49800-49818. |
| Unit | Piece |
| Specification | 5mg 10mM*1mL in DMSO 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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