Ibrutinib_Protein Tyrosine Kinase/PTK_Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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CAS	936563-96-1
Content	HPLC≥98%
Chinese Name	依鲁替尼
English Name	Ibrutinib
Synonym	PCI-32765
Unit	Piece
Purity	HPLC≥98%
Molecular Formula	C₂₅H₂₄N₆O₂
Molecular Weight	440.5
Appearance	White to off-white solid
Storage	Powder : -20℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO≥5mg/ml
EC	EINECS 805-642-2
MDL	MFCD20261150
InChIKey	XYFPWWZEPKGCCK-GOSISDBHSA-N
InChI	InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m1/s1
PubChem CID	24821094
SMILES	C=CC(N1C[C@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C5=C(N)N=CN=C52)CCC1)=O
Description	Ibrutinib is a small molecule BTK inhibitor that selectively covalently binds to the cysteine residue (Cys-481) on the active site of BTK, irreversibly inhibits the activity of BTK, thereby inhibiting BCR activation of signaling pathways.
Target Point	Btk
Passage	Protein Tyrosine Kinase/RTK;Angiogenesis
IC50	IC50: 0.5 nM (Btk)
Data Literature Source	[1]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20; 107 (29) :13075-80. [2]. Herman SE, et al. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood. 2011 Jun 9; 117 (23) :6287-96. [3]. Chang BY, et al. The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells. Arthritis Res Ther. 2011 Jul 13; 13 (4) :R115. [4]. Wu H, et al. Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model. Sci Rep. 2017 Mar 28; 7 (1) :466.
Specification	10mg 10mM*1mL in DMSO 50mg 100mg