BMS-754807_IGF-1R_Protein Tyrosine Kinase/RTK _Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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CAS	1001350-96-4
Content	Purity≥98%
English Name	BMS-754807
Synonym	BMS754807
Unit	Piece
Purity	≥98%
Molecular Formula	C₂₃H₂₄FN₉O
Molecular Weight	461.49
Appearance	White to off-white solid
Storage	Powder : -20℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO
MDL	MFCD18633202
InChIKey	LQVXSNNAFNGRAH-QHCPKHFHSA-N
InChI	InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m0/s1
PubChem CID	24785538
SMILES	FC1=CC=C(NC([C@@]2(C)N(C(N=C3NC4=NNC(C5CC5)=C4)=NN6C3=CC=C6)CCC2)=O)C=N1
Description	BMS-754807 is a potent, reversible insulin-like growth factor 1 receptor/insulin receptor inhibitor.
Target Point	IGF-1R inhibitor
Passage	Protein Tyrosine Kinase/RTK
Data Literature Source	[1]. Carboni JM, et al. BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR. Mol Cancer Ther, 2009, 8(12), 3341-3349. [2]. Wittman MD, et al. Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development. J Med Chem, 2009, 52(23), 7360-7363. [3]. Kolb EA, et al. Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program. Pediatr Blood Cancer, 2011, 56(4), 595-603. [4]. Franks SE, et al. BMS-754807 is cytotoxic to non-small cell lung cancer cells and enhances the effects of platinum chemotherapeutics in the human lung cancer cell line A549. BMC Res Notes. 2016 Mar 1;9:134.
Specification	2mg 5mg 10mM*1mL in DMSO 10mg