CAS |
155206-00-1 |
Chinese Name |
比马前列素 |
English Name |
Bimatoprost |
Synonyms |
比马前列素;17-Phenyl-tri-nor;PLX33; |
Molecular Formula |
C25H37NO4 |
Molecular Weight |
415.57 |
Solubility |
Soluble in DMSO |
Purity |
≥98% |
Appearance |
White to off-white Solid |
Storage |
Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC |
EINECS 642-890-9 |
MDL |
MFCD03411999 |
SMILES |
O=C(NCC)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C[C@@H]1O |
InChIKey |
AQOKCDNYWBIDND-FTOWTWDKSA-N |
InChI |
InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1 |
PubChem CID |
5311027 |
Target Point |
Prostaglandin Receptor |
Passage |
Endocrinology & Hormones;GPCR & G Protein |
Background |
Bimatoprost is a prostaglandin analog. |
In Vitro |
Bimatoprost持续引起在同一组织制备内的不同细胞中的反应,而前列腺素F(2a)和17-苯基前列腺素F(2α)刺激相同的细胞反应。Bimatoprost选择性地刺激在不同的猫的虹膜括约肌细胞内的钙信号。[2] |
In Vivo |
在分离的猫虹膜括约肌制剂中研究了比马前列素对 Cyr61 和 CTGF 的影响,该组织对前列腺酰胺高度敏感。比马前列素上调猫虹膜组织中 Cyr61 mRNA 的表达。[1] |
Data Literature Source |
[1]Liang Y,Li C,Guzman VM,Evinger AJ 3rd,Protzman CE,Krauss AH,Woodward DF. Comparison of prostaglandin F2alpha,bimatoprost (prostamide),and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression. J Biol Chem. 2003 Jul 18;278(29):27267-77. [2]Spada CS,Krauss AH,Woodward DF,Chen J,Protzman CE,Nieves AL,Wheeler LA,Scott DF,Sachs G. Bimatoprost and prostaglandin F(2 alpha) selectively stimulate intracellular calcium signaling in different cat iris sphincter cells. Exp Eye Res. 2005 Jan;80(1):135-45. |
Unit |
Piece |
Specification |
5mg 10mM*1mL in DMSO 10mg 50mg |