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Go 6983

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Cat.No：IG1020 Solarbio

CAS：133053-19-7

Molecular Formula：C₂₆H₂₆N₄O₃

Molecular Weight：442.51

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	133053-19-7
Name	Go 6983
Molecular Formula	C₂₆H₂₆N₄O₃
Molecular Weight	442.51
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD04040031
SMILES	O=C(C(C1=CN(CCCN(C)C)C2=C1C=C(OC)C=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O
InChIKey	LLJJDLHGZUOMQP-UHFFFAOYSA-N
InChI	InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
PubChem CID	3499
Target Point	PKC
Passage	TGF-beta/Smad;Epigenetics
Background	Go 6983 is a potent PKC inhibitor.
Biological Activity	Go 6983 是一种有效的 PKC 抑制剂，能够作用于 PKCα，PKCβ，PKCγ，PKCδ 和 PKCζ，IC50 值分别为 7 nM，7 nM，6 nM，10 nM 和 60 nM[1-3]。
Data Literature Source	[1]. Gschwendt M，et al. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett，1996，392(2)，77-80. [2]. Peterman EE，et al. G0 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J Cardiovasc Pharmacol，2004，43(5)，645-656. [3]. Young LH，et al. G0 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev，2005，23(3)，255-272
Unit	Piece
Specification	5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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