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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > H-89 dihydrochlorideCAS：130964-39-5
Molecular Formula：C20H20BrN3O2S·2HCl
Molecular Weight：519.28
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 130964-39-5 |
| Name | H-89 dihydrochloride |
| Molecular Formula | C20H20BrN3O2S·2HCl |
| Molecular Weight | 519.28 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00214120 |
| SMILES | O=S(C1=CC=CC2=C1C=CN=C2)(NCCNC/C=C/C3=CC=C(Br)C=C3)=O.Cl.Cl |
| InChIKey | GELOGQJVGPIKAM-WTVBWJGASA-N |
| InChI | InChI=1S/C20H20BrN3O2S.2ClH/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;/h1-10,12,15,22,24H,11,13-14H2;2*1H/b3-2+;; |
| PubChem CID | 5702541 |
| Target Point | S6K1;PKA inhibitor |
| Passage | Stem Cells; Protein Tyrosine Kinase/RTK |
| Background | H-89 dihydrochloride is a protein kinase A (PKA) inhibitor. |
| Biological Activity | H-89 dihydrochloride 是PKA 抑制剂， IC50 值为 48 nM。也可轻微抑制 PKG，PKC，酪蛋白激酶活性[1-3]。 |
| IC50 | 48nM(protein kinase A)[1-3] |
| Data Literature Source | [1]. Chijiwa T，et al. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase，N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89)，of PC12D [2]. Blazev R，et al. Effects of the PKA inhibitor H-89 on excitation-contraction coupling in skinned and intact skeletal muscle fibres. J Muscle Res Cell Motil. 2001;22(3):277-86. [3]. Hosseini-Zare MS，et al. Effects of pentoxifylline and H-89 on epileptogenic activity of bucladesine in pentylenetetrazol-treated mice. Eur J Pharmacol. 2011 Nov 30;670(2-3):464-70. |
| Unit | Piece |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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这个可以用水溶解吗 2022-08-22 12:14:17
Administrator本产品在水中的溶解度低，若需要高浓度工作液，可以考虑用DMSO溶解
本产品的溶解度：
Soluble in Water ≥ 1 mg/mL(Need ultrasonic)
Soluble in DMSO ≥ 10 mg/mL