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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > ICG-001CAS：780757-88-2
Molecular Formula：C33H32N4O4
Molecular Weight：548.63
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 780757-88-2 |
| Name | ICG-001 |
| Molecular Formula | C33H32N4O4 |
| Molecular Weight | 548.63 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12196918 |
| SMILES | O=C(NCC1=CC=CC=C1)N2CCC(N([C@@]2(CN(C3=O)CC4=C5C=CC=CC5=CC=C4)[H])[C@H]3CC6=CC=C(C=C6)O)=O |
| InChIKey | HQWTUOLCGKIECB-XZWHSSHBSA-N |
| InChI | InChI=1S/C33H32N4O4/c38-27-15-13-23(14-16-27)19-29-32(40)35(21-26-11-6-10-25-9-4-5-12-28(25)26)22-30-36(18-17-31(39)37(29)30)33(41)34-20-24-7-2-1-3-8-24/h1-16,29-30,38H,17-22H2,(H,34,41)/t29-,30+/m0/s1 |
| PubChem CID | 11238147 |
| Target Point | β-catenin |
| Passage | Stem Cells |
| Background | Icariin is a flavonol glycoside that inhibits PDE5 and PDE4 activity. Also a PPARα activator. |
| Biological Activity | ICG-001是β-catenin/TCF介导的转录抑制剂。 它特异性结合 CREB 蛋白起作用，IC50 为3 μM。[1-4] |
| IC50 | 3μM(CBP)[1-4] |
| Data Literature Source | [1]. Yan D，et al，Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways. J Biol Chem，2012，287(11)，8598-8612. [2]. Henderson WR Jr，et al，Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci USA，2010，107(32)，14309-14314. [3]. Emami KH，et al. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci USA，2004，101(34)，12682-12687. [4]. Liu Y，et al. ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population. J Exp Clin Cancer Res. 2017 Sep 11;36(1):125. |
| Unit | Piece |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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