CAS |
780757-88-2 |
Content |
Purity≥98% |
Chinese Name |
2,3-二氢-1,4-苯并恶嗪 |
English Name |
ICG-001 |
Synonym |
PRI-724,PRI-724isomer |
Unit |
Piece |
Purity |
≥98% |
Molecular Formula |
C33H32N4O4 |
Molecular Weight |
548.63 |
Appearance |
White to off-white solid |
Storage |
Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in DMSO |
MDL |
MFCD12196918 |
InChIKey |
HQWTUOLCGKIECB-XZWHSSHBSA-N |
InChI |
InChI=1S/C33H32N4O4/c38-27-15-13-23(14-16-27)19-29-32(40)35(21-26-11-6-10-25-9-4-5-12-28(25)26)22-30-36(18-17-31(39)37(29)30)33(41)34-20-24-7-2-1-3-8-24/h1-16,29-30,38H,17-22H2,(H,34,41)/t29-,30+/m0/s1 |
PubChem CID |
11238147 |
SMILES |
O=C(NCC1=CC=CC=C1)N2CCC(N([C@@]2(CN(C3=O)CC4=C5C=CC=CC5=CC=C4)[H])[C@H]3CC6=CC=C(C=C6)O)=O |
Description |
Icariin is a flavonol glycoside that inhibits PDE5 and PDE4 activity. Also a PPARα activator. |
Target Point |
β-catenin |
Passage |
Stem Cells |
IC50 |
3 μM (CBP)[1-4] |
Data Literature Source |
[1]. Yan D, et al, Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways. J Biol Chem, 2012, 287(11), 8598-8612.
[2]. Henderson WR Jr, et al, Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci USA, 2010, 107(32), 14309-14314.
[3]. Emami KH, et al. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci USA, 2004, 101(34), 12682-12687.
[4]. Liu Y, et al. ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population. J Exp Clin Cancer Res. 2017 Sep 11;36(1):125. |
Specification |
5mg 10mg |