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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > IWR-1CAS：1127442-82-3
Molecular Formula：C25H19N3O3
Molecular Weight：409.44
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1127442-82-3 |
| Name | IWR-1 |
| Molecular Formula | C25H19N3O3 |
| Molecular Weight | 409.44 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18086875 |
| SMILES | O=C(NC1=C2N=CC=CC2=CC=C1)C3=CC=C(N(C([C@]4([H])[C@](C5)([H])C=C[C@]5([H])[C@]64[H])=O)C6=O)C=C3 |
| InChIKey | ZGSXEXBYLJIOGF-ALFLXDJESA-N |
| InChI | InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+ |
| PubChem CID | 44483163 |
| Target Point | Wnt |
| Passage | Stem Cells |
| Background | IWR-1 is a tankyrase inhibitor that inhibits the Wnt/β-catenin signaling pathway. |
| Biological Activity | IWR-1是端锚聚合酶抑制剂，抑制Wnt/β-catenin信号传导途径。[1-3] |
| IC50 | 180nM(Wnt)[1-3] |
| Data Literature Source | [1]. Lu J，et al. Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3825-7. [2]. Zhang X，et al. Macrophage migration inhibitory factor promotes proliferation and neuronal differentiation of neural stem/precursor cells through Wnt/β-catenin signal pathway. Int J Biol Sci. 2013 Nov 28;9(10):1108-20. [3]. Gupta PS，et al. Regulation and Regulatory Role of WNT Signaling in Potentiating FSH Action during Bovine Dominant Follicle Selection. PLoS One. 2014 Jun 17;9(6):e100201. |
| Unit | Piece |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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Hepatic lipid metabolism disorders and immunotoxicity induced by cysteamine in early developmental stages of zebrafish
Click to check >>Author：Chao Chen, Yuhua Zuo, Hongmei Hu, Xue Li, Li Zhang, Dou Yang, Fasheng Liu, Xinjun Liao, Guanghua Xiong, Zigang Cao, Zilin Zhong, Yanlong Bi, Huiqiang Lu, Jianjun Chen
IF：4.5710
Publish_to：TOXICOLOGY
PMID：37236339
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