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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > JSH 23CAS：749886-87-1
Molecular Formula：C16H20N2
Molecular Weight：240.34
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 749886-87-1 |
| Name | JSH 23 |
| Molecular Formula | C16H20N2 |
| Molecular Weight | 240.34 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09753595 |
| SMILES | NC1=CC(C)=CC=C1NCCCC2=CC=CC=C2 |
| InChIKey | YMFNPBSZFWXMAD-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3 |
| PubChem CID | 16760588 |
| Target Point | NF-kB |
| Passage | NF-κB |
| Background | JSH-23 is an NF-κB inhibitor. |
| Biological Activity | JSH-23是 NF-κB 抑制剂，抑制NF-κB转录活性，IC50 为7.1 μM。SH-23以剂量依赖性方式抑制脂多糖（LPS）诱导的染色质浓缩，对应于3μM时44±4％抑制，10μM时为63±5％，30μM时为93±3％。 [1-4] |
| Data Literature Source | [1]. Shin，H.M.，et al. Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation. FEBS Lett，2004. 571(1-3): p. 50-4. [2]. Arias-Salvatierra，D.，et al. Role of nitric oxide produced by iNOS through NF-kappaB pathway in migration of cerebellar granule neurons induced by Lipopolysaccharide. Cell Signal，2011. 23(2): p. 425-35. [3]. Kasparkova，J.，et al. Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer. FEBS J，2014. 281(5): p. 1393-408. [4]. Kumar，A.，et al. JSH-23 targets nuclear factor-kappa B and reverses various deficits in experimental diabetic neuropathy: effect on neuroinflammation and antioxidant defence. Diabetes Obes Metab，2011. 13(8): p. 750-8 |
| Unit | Piece |
| Specification | 5mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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