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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > TGF-β/Smad > KartogeninCAS：4727-31-5
Molecular Formula：C20H15NO3
Molecular Weight：317.34
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 4727-31-5 |
| Name | Kartogenin |
| Molecular Formula | C20H15NO3 |
| Molecular Weight | 317.34 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00560510 |
| SMILES | O=C(O)C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O |
| InChIKey | SLUINPGXGFUMLL-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24) |
| PubChem CID | 2826191 |
| Target Point | Smad4，Smad5 |
| Passage | TGF-beta/Smad;Stem Cells |
| Background | Kartogenin is an activator/inducer of the smad4/smad5 pathway. |
| Biological Activity | Kartogenin是人类间充质干细胞分化成软骨细胞的诱导剂。[1-3] |
| Data Literature Source | [1]. Zhang J，et al. Kartogenin induces cartilage-like tissue formation in tendon-bone junction. Bone Res. 2014;2. pii: 14008. [2]. Wang J，et al. A heterocyclic molecule kartogenin induces collagen synthesis of human dermal fibroblasts by activating the smad4/smad5 pathway. Biochem Biophys Res Commun. 2014 Jul 18;450(1):568-74. [3]. Ono Y，et al. Chondroprotective Effect of Kartogenin on CD44-Mediated Functions in Articular Cartilage and Chondrocytes. Cartilage. 2014 Jul;5(3):172-80. |
| Unit | Piece |
| Specification | 1mg 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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