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LGK974

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Cat.No：IL0680 Solarbio

CAS：1243244-14-5

Molecular Formula：C₂₃H₂₀N₆O

Molecular Weight：396.44

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to brown Solid

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Product Information

CAS	1243244-14-5
Name	LGK974
Molecular Formula	C₂₃H₂₀N₆O
Molecular Weight	396.44
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to brown Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD27501026
SMILES	O=C(NC1=NC=C(C2=NC=CN=C2)C=C1)CC3=CN=C(C4=CC(C)=NC=C4)C(C)=C3
InChIKey	XXYGTCZJJLTAGH-UHFFFAOYSA-N
InChI	InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)
PubChem CID	46926973
Target Point	Porcupine
Passage	Stem Cells
Background	LGK974 is a potent and specific Porcupine (PORCN) inhibitor.
Biological Activity	LGK974是一种有效且特异性的 Porcupine (PORCN) 抑制剂, IC50 为0.1 nM[1]。
IC50	IC50:0.1nM Porcupine[1]
Data Literature Source	[1]. Liu J， et al. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A. 2013 Dec 10; 110 (50) :20224-9. [2]. Tammela T， et al. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Nature. 2017 May 18; 545 (7654) :355-359.
Unit	Piece
Specification	2mg 5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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