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My CartCAS：22373-78-0
Molecular Formula：C36H61NaO11
Molecular Weight：692.85
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 22373-78-0 |
| Name | Monensin Sodium Salt |
| Molecular Formula | C36H61NaO11 |
| Molecular Weight | 692.85 |
| Solubility | Soluble in Ethanol ≥100mg/mL;Soluble in DMSO ＜ 1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 244-941-7 |
| MDL | MFCD26960926 |
| SMILES | OC[C@@]1(O)[C@H](C)C[C@H](C)[C@]([C@@]2(O[C@]([C@@]3(CC[C@@]([C@]4(O[C@@]5(C[C@H](O)[C@@H](C)[C@@]([H])([C@H]([C@@H](OC)[C@H](C)C([O-])=O)C)O5)CC4)C)([H])O3)CC)([H])[C@@H](C)C2)[H])([H])O1.[Na+] |
| InChIKey | XOIQMTLWECTKJL-FBZUZRIGSA-M |
| InChI | InChI=1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35+,36-;/m0./s1 |
| PubChem CID | 23667299 |
| Target Point | Bacterial; Antibiotic; Na+/H+ Exchanger (NHE) |
| Passage | Anti-infection; Membrane Transporter/Ion Channel |
| Background | It is an ionic carrier antibiotic and an ionic carrier that mediates Na+/H+exchange. It is a commonly used protein transport inhibitor, which can destroy Golgi apparatus and inhibit intracellular protein transport. |
| Biological Activity | Monensin sodium salt 是由肉桂链霉菌 (Streptomyces cinnamonensis) 分泌的抗生素。[1-2] |
| Data Literature Source | [1]. Dayekh K，et al. Monensin inhibits epidermal growth factor receptor trafficking and activation: synergistic cytotoxicity in combination with EGFR inhibitors. Mol Cancer Ther. 2014 Nov;13(11):2559-71. [2]. Tumova L，et al. Monensin inhibits canonical Wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice. Mol Cancer Ther. 2014 Apr;13(4):812-22. |
| Unit | Piece |
| Specification | 100mg 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
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