{{cart_num}}
My CartCAS：129618-40-2
Molecular Formula：C15H14N4O
Molecular Weight：266.3
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 129618-40-2 |
| Name | Nevirapine |
| Molecular Formula | C15H14N4O |
| Molecular Weight | 266.3 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 603-345-0 |
| MDL | MFCD00866928 |
| SMILES | O=C1C2=C(N=CC=C2)N(C3CC3)C4=NC=CC(C)=C4N1 |
| InChIKey | NQDJXKOVJZTUJA-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20) |
| PubChem CID | 4463 |
| Target Point | HIV |
| Passage | Anti-infection |
| Background | Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase. |
| Biological Activity | Nevirapine是用于治疗和预防HIV/AIDS的HIV-1逆转录酶非核苷抑制剂，Ki值为270 μM。[1-5] |
| Data Literature Source | [1]. Erickson DA，et al. Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitornevirapine by human hepatic cytochromes P-450. Drug Metab Dispos. 1999 Dec;27(12):1488-95. [2]. Dong JJ，et al. In vitro evaluation of the therapeutic potential of nevirapine in treatment of human thyroid anaplastic carcinoma. Mol Cell Endocrinol. 2013 May 6;370(1-2):113-8. [3]. Merluzzi VJ，et al. Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor. Science. 1990 Dec 7;250(4986):1411-3. [4]. Riska PS，et al. Biotransformation of nevirapine，a non-nucleoside HIV-1 reverse transcriptase inhibitor，in mice，rats，rabbits，dogs，monkeys，and chimpanzees. Drug Metab Dispos. 1999 Dec;27(12):1434-47. [5]. Onasanwo SA，et al. Evaluation of anti-ulcerogenic and ulcer-healing activities of nevirapine in rats. Afr J Med Med Sci. 2015 Sep;44(3):251-9. |
| Unit | Piece |
| Specification | 10mg 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
